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首页»科研成果» 2014
徐冰首席团队在PNAS发表论文
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Avian influenza H5N1 viral and bird migration networks in Asia Huaiyu Tiana,1, Sen Zhoub,1, Lu Dongc,1, Thomas P. Van Boeckeld,1, Yujun Cuie,1, Yarong Wue, Bernard Cazellesf,g, Shanqian Huanga, Ruifu Yange, Bryan T. Grenfelld,h,2, and Bing Xua,b,i,2 a State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing 100875, People’s Republic of China; b Ministry of Education Key Laboratory for Earth System Modelling, Center for Earth System Science, and School of Environment, Tsinghua University, Beijing 100084, People’s Republic of China; c Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering, College of Life Sciences, Beijing Normal University, Beijing 100875, People’s Republic of China; d Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544; e State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, People’s Republic of China; f Ecologie et Evolution, UMR 7625, Université Pierre et Marie Curie, Centre National de la Recherche Scientifique et Ecole Normale Supérieure, 75230 Paris Cedex 05, France; g Unité de Modélisation Mathématique et Informatique des Systémes Complexes, Unité Mixte Internationale 209, Institut de Recherche pour le Développement et Université Pierre et Marie Curie, 93142 Bondy Cedex, France; h Fogarty International Center, National Institutes of Health, Bethesda, MD 20892; and I Department of Geography, University of Utah, Salt Lake City, UT 84112 Edited by Burton H. Singer, University of Florida, Gainesville, FL, and approved November 26, 2014 (received for review March 20, 2014) ABSTRACT The spatial spread of the highly pathogenic avian influenza virus H5N1 and its long-term persistence in Asia have resulted in avian influenza panzootics and enormous economic losses in the poultry sector. However, an understanding of the regional long-distance transmission and seasonal patterns of the virus is still lacking. In this study, we present a phylogeographic approach to reconstruct the viral migration network. We show that within each wild fowl migratory flyway, the timing of H5N1 outbreaks and viral migrations are closely associated, but little viral transmission was observed between the flyways. The bird migration network is shown to better reflect the observed viral gene sequence data than other networks and contributes to seasonal H5N1 epidemics in local regions and its large-scale transmission along flyways. These findings have potentially far-reaching consequences, improving our understanding of how bird migration drives the periodic reemergence of H5N1 in Asia. KEY WORDS: bird migration; HPAI H5N1; viral migration; network; satellite tracking PUBLISHED BY: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, doi: 10.1073/pnas.1405216112 |
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